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The American Journal of Psychiatry, VOL. 149, No. 11

REGULAR ARTICLES | November 01, 1992

Hyperventilation-induced cerebral ischemia in panic disorder and effect of nimodipine

Am J Psychiatry 1992;149:1589-1591.

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Abstract

Basilar artery blood flow was measured by transcranial Doppler ultrasonography before and during hyperventilation in nine patients with panic disorder and nine normal comparison subjects. The hyperventilation-induced decrease in basilar artery blood flow was significantly greater in patients with panic attacks than in comparison subjects. Two patients with decreases in basilar flow greater than 80% were successfully treated with nimodipine, a centrally active calcium channel blocker.

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