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The American Journal of Psychiatry, VOL. 149, No. 1

REGULAR ARTICLES | January 01, 1992

Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients

Am J Psychiatry 1992;149:118-120.

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Abstract

The authors measured intracellular Ca2+ concentrations in four manic and five bipolar depressed patients and seven comparison subjects. Platelet and lymphocyte intracellular Ca2+ concentrations were comparable. The patients' mean intracellular Ca2+ concentrations were higher than those of the comparison subjects and demonstrated more interindividual variation. These findings suggest a diffuse abnormality in mechanisms affecting intracellular calcium homeostasis in bipolar disorder.

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