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The American Journal of Psychiatry, VOL. 148, No. 5

REGULAR ARTICLES | May 01, 1991

Imipramine treatment of methadone maintenance patients with affective disorder and illicit drug use

Am J Psychiatry 1991;148:667-669.

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Abstract

Of 17 consecutive patients receiving methadone maintenance treatment who had primary or chronic depression, nine (53%) improved in both mood and drug abuse after imipramine treatment. This finding suggests a potential for helping such dual-diagnosis patients reduce drug abuse and associated risk for HIV. Further controlled trials are warranted.

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