Hospitalized patients were divided into nonpsychotic severely depressed
(N = 53), nonpsychotic moderately depressed (N = 54), and psychotic
depressed (N = 25) groups and treated with either imipramine or
amitriptyline, up to 250 mg/day, for 4 weeks. Good response occurred in 39%
of the 38 severely depressed, 67% of the 49 moderately depressed, and 32%
of the 19 psychotic depressed patients who completed treatment. The
response of the patients with nonpsychotic severe depression did not differ
significantly from the response of those with psychotic depression, and
both groups fared worse than the group with nonpsychotic moderate
depression.Abstract Teaser