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The American Journal of Psychiatry, VOL. 147, No. 11

REGULAR ARTICLES | November 01, 1990

Influence of patient-related variables on clozapine plasma levels

Am J Psychiatry 1990;147:1471-1475.

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Abstract

The authors investigated the clozapine plasma levels of 148 psychiatric inpatients. Multiple regression analysis revealed a linear relationship between dose of clozapine and plasma concentrations. The analysis showed a significant influence of dose, sex, smoking, weight, and age on the plasma concentrations of clozapine under clinical conditions. These results remained significant when clozapine doses below 150 mg/day and above 500 mg/day were excluded from the analysis.

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