Two previously reported neuroimaging studies from the authors'
laboratory demonstrated larger lateral ventricles in schizophrenic patients
than in normal control subjects. This diagnostic effect was accounted for
almost entirely by the male subjects. In this report the role of gender is
further explored through reexamining these data sets and those of two
earlier studies. Although Gender by Diagnosis effects were not
demonstrated, in three of the four studies male schizophrenic subjects had
significantly larger ventricles than their control counterparts; there were
no differences among the female subjects. One study suggested the opposite
effect, but this may be attributable to a non-representative control
group.Abstract Teaser