Among 48 patients with diagnoses of depression according to DSM-III,
there was a significant relation between therapeutic failure of unilateral
ECT, as measured by scores on the Hamilton Rating Scale for Depression, and
the concomitant use of a benzodiazepine. Of the 34 patients who showed a
good therapeutic response to unilateral ECT, those taking benzodiazepines
had smaller changes in their Hamilton depression ratings from before
treatment to after treatment and were more symptomatic at the end of the
course of ECT. Thus, when patients take benzodiazepines during a course of
unilateral ECT, the maximum therapeutic response may be compromised.Abstract Teaser