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The American Journal of Psychiatry, VOL. 146, No. 7

REGULAR ARTICLES | July 01, 1989

Open trial of fluoxetine in obsessive-compulsive disorder

Am J Psychiatry 1989;146:909-911.

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Abstract

A 12-week open trial of fluoxetine in 61 obsessive-compulsive disorder patients significantly improved depressive and obsessive-compulsive symptoms. Baseline depression scores were not related to improvement on two obsessive-compulsive scales. The results reinforce the hypothesis of serotonergic abnormalities in obsessive-compulsive disorder.

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