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The American Journal of Psychiatry, VOL. 145, No. 8

REGULAR ARTICLES | August 01, 1988

Imipramine and social-vocational adjustment in chronic depression

Am J Psychiatry 1988;145:997-999.

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Abstract

The authors compared the effects of 6 weeks of imipramine treatment with 6 weeks of placebo treatment on social and vocational impairment in chronic depression. Imipramine was associated with significantly greater pre- to posttreatment improvement of social-vocational impairments in chronic depression, suggesting that these impairments may have represented affective symptoms rather than characterologic deficits.

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