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The American Journal of Psychiatry, VOL. 145, No. 6

REGULAR ARTICLES | June 01, 1988

Prolactin response to tryptophan during mianserin treatment

Am J Psychiatry 1988;145:740-741.

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Abstract

Unlike tricyclic antidepressants and monoamine oxidase inhibitors, mianserin did not increase prolactin response to the 5- hydroxytryptamine (5-HT) precursor tryptophan in nine patients with major depression. Antidepressant drugs apparently produce dissimilar effects on this aspect of brain 5-HT function in depressed patients.

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