An open study of the therapeutic effects of low-dose neuroleptic
treatment was performed on 12 consecutively hospitalized children, aged
7-11, who satisfied DSM-III criteria for childhood-onset pervasive
developmental disorder. While receiving an average dose of 0.04 mg/kg per
day of haloperidol or fluphenazine hydrochloride, the patients exhibited
significant reductions in hyperactivity and aggressive symptoms and
significant improvement in peer relations. This dose of neuroleptic was
associated with minimal side effects. The authors conclude that low doses
of potent neuroleptics may be effective treatment for some patients
suffering from childhood-onset pervasive developmental disorder.Abstract Teaser