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The American Journal of Psychiatry, VOL. 145, No. 9

REGULAR ARTICLES | September 01, 1988

Anterior pituitary, adrenal, and gonadal hormones during cocaine withdrawal

Am J Psychiatry 1988;145:1094-1098.

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Abstract

Plasma luteinizing hormone (LH), prolactin, testosterone, and cortisol levels were determined in 16 patients after hospital admission for cocaine abuse, during the course of 4 weeks of hospitalization, and before discharge. Hyperprolactinemia was found at admission (mean +/- SD, 27.5 +/- 10.2 ng/ml) and persisted until discharge (mean +/- SD, 28.7 +/- 10.8 ng/ml). Plasma LH, testosterone, and cortisol levels were within normal limits. These findings suggest that persistent elevation of plasma prolactin levels after cocaine withdrawal may reflect a chronic cocaine-induced derangement in neural dopaminergic regulatory systems.

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