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The American Journal of Psychiatry, VOL. 144, No. 3

REGULAR ARTICLES | March 01, 1987

Prediction of response to nortriptyline and phenelzine by platelet MAO activity

Am J Psychiatry 1987;144:338-340.

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Abstract

Thirty-seven depressed patients over the age of 55 were treated for 5-7 weeks with either nortriptyline, a tricyclic antidepressant, or phenelzine, a monoamine oxidase (MAO) inhibitor. Patients' platelet MAO activity was measured following a drug washout period before treatment. Patients with higher MAO activity had a better response to treatment, regardless of which drug was used.

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