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The American Journal of Psychiatry, VOL. 144, No. 8

REGULAR ARTICLES | August 01, 1987

CO2 challenge of patients with panic disorder

Am J Psychiatry 1987;144:1080-1082.

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Abstract

In an open trial, five of eight panic disorder patients and none of five control subjects panicked after inhalation of two breaths of 35% CO2 and 65% O2; none panicked after placebo. Using 35% CO2 to induce panic is safe, simple, and well tolerated and may provide a valuable laboratory model of panic.

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