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The American Journal of Psychiatry, VOL. 143, No. 12

REGULAR ARTICLES | December 01, 1986

Symptoms of neuroleptic malignant syndrome in 82 consecutive inpatients

Am J Psychiatry 1986;143:1587-1590.

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Abstract

This study, a retrospective chart review of 82 consecutive male inpatients, assessed the spectrum and prevalence of neuroleptic malignant syndrome. The prevalence of diagnosed neuroleptic malignant syndrome (2.4%) was greater than that generally reported. Eight additional patients manifested symptoms that abated without cessation of neuroleptic treatment. This suggests that neuroleptic malignant syndrome is a spectrum disorder that has milder variants. Affective illness may be a risk factor for its development.

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