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The American Journal of Psychiatry, VOL. 143, No. 9

REGULAR ARTICLES | September 01, 1986

Exacerbation of schizophrenia associated with amantadine

Am J Psychiatry 1986;143:1170-1171.

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Abstract

Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication. Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.

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