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The American Journal of Psychiatry, VOL. 142, No. 10

Special Articles | October 01, 1985

Neuroleptic malignant syndrome

Am J Psychiatry 1985;142:1137-1145.

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Abstract

Neuroleptic malignant syndrome is a rare but serious adverse effect of antipsychotic medication. The author describes three new cases and reviews 50 others published in the past 5 years. Demographic and clinical features, diagnosis, treatment, outcome, and pathophysiology are critically reviewed, and a new set of diagnostic criteria, incorporating physical signs and routine laboratory tests, is proposed.

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