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The American Journal of Psychiatry, VOL. 141, No. 4

REGULAR ARTICLES | April 01, 1984

Rate-sensitive inhibition of ACTH release in depression

Am J Psychiatry 1984;141:590-592.

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Abstract

Rate-sensitive inhibition of ACTH release is abnormal in Cushing's disease but uncharacterized in depression. The authors found that two of 10 depressed patients had paradoxical responses, suggesting the existence of a hypothalamic-pituitary-adrenal axis abnormality in depression that is independent of dexamethasone suppression test results.

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