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The American Journal of Psychiatry, VOL. 141, No. 1

REGULAR ARTICLES | January 01, 1984

Mood-elevating effect of captopril in depressed patients

Am J Psychiatry 1984;141:110-111.

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Abstract

The use of captopril, an inhibitor of angiotensin-converting enzyme and enkephalinase, was associated with substantial mood elevation in three depressed patients. Substances that may alter neuropeptide synthesis or degradation warrant further investigation as therapeutic agents in certain neuropsychiatric disorders.

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