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The American Journal of Psychiatry, VOL. 140, No. 4

Brief Reports | April 01, 1983

L-5-hydroxytryptophan for LSD-induced psychosis

Am J Psychiatry 1983;140:456-458.

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Abstract

The serotonin precursor L-5-hydroxytryptophan reversed the symptoms of a 23-year-old man suffering from LSD-induced psychosis who participated in a randomized, double-blind crossover study of the drug and a placebo. This finding is compatible with the speculation that some LSD- induced psychotic disorders may be caused by a relative deficiency of CNS serotonin.

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