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The American Journal of Psychiatry, VOL. 140, No. 3

REGULAR ARTICLES | March 01, 1983

Effects of weight loss on the dexamethasone suppression test

Am J Psychiatry 1983;140:338-341.

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Abstract

The authors studied postdexamethasone cortisol secretion in 18 depression-free, healthy, obese subjects before and after weight loss. Although all subjects suppressed cortisol normally before weight loss, 5 of 18 (27.5%) failed to suppress cortisol after an average loss of 13.5 kg. This failure to suppress cortisol was not associated with any change in depression ratings.

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