The authors describe two patients with organic psychosis who had vitamin
B12 deficiency and no hematologic or spinal cord abnormalities. They review
the literature that supports a causal relationship between B12 deficiency
and cerebral dysfunction, as measured by the EEG, and consequent organic
mental changes. The authors cite evidence that these EEG and organic mental
changes are reversible with B12 replacement. They emphasize that
psychiatric manifestations may be the first symptoms of vitamin B12
deficiency and thus antedate anemia and spinal cord disease. They recommend
consideration of B12 deficiency and serum B12 determinations in all
patients with organic mental symptoms.Abstract Teaser