Low basal plasma testosterone levels with normal response to human
chorionic gonadotropin (HCG) stimulation and mild hyperprolactinemia and
blunted luteinizing hormone (LH) response to luteinizing-releasing hormone
(LRH) stimulation were found in 10 adolescent schizophrenic boys who had
been treated with chlorpromazine for more than 6 months. These findings may
indicate a disturbance of the hypothalamic-pituitary- gonadal function in
these patients, probably due to the prolonged administration of
chlorpromazine. It remains to be established whether the decrease in basal
testosterone secretion is caused directly by chlorpromazine or secondarily
by the drug-induced hyperprolactinemia.Abstract Teaser