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The American Journal of Psychiatry, VOL. 139, No. 6

REGULAR ARTICLES | June 01, 1982

Demeclocycline in the prophylaxis of self-induced water intoxication

Am J Psychiatry 1982;139:828-830.

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Abstract

Demeclocycline, a competitive inhibitor of antidiuretic hormone at renal tubules, was studied in a patient with the syndrome of psychosis, psychogenic polydipsia, and episodic water intoxication. Under double- blind, placebo-controlled conditions, demeclocycline substantially reduced the severity and frequency of hyponatremic episodes.

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