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The American Journal of Psychiatry, VOL. 139, No. 6

REGULAR ARTICLES | June 01, 1982

Tricyclic-antidepressant-induced delirium and plasma drug concentration

Am J Psychiatry 1982;139:822-823.

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Abstract

Fourteen patients receiving routine doses of amitriptyline developed plasma drug concentrations above 300 ng/ml. Of the 7 patients with plasma levels above 450 ng/ml, 6 developed a drug-induced delirium as opposed to none of the 7 with levels below 450 ng/ml. Thus, this adverse effect could be avoided by monitoring levels and reducing dosage when appropriate.

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