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The American Journal of Psychiatry, VOL. 139, No. 10

REGULAR ARTICLES | October 01, 1982

Neuroendocrine risk factors of suicidal behavior

Am J Psychiatry 1982;139:1323-1325.

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Abstract

Three of 22 subjects in a study of neuroendocrine correlates of clinical change made serious suicide attempts, 2 of which were lethal. The suicidal subjects had significantly higher 24-hour urinary cortisol levels and significantly lower 24-hour urinary norepinephrine-to- epinephrine ratios than the nonsuicidal patients had. Although the cortisol finding confirms earlier reports, the norepinephrine-to- epinephrine ratio finding is new. The results support the concept that the clinical utility of neuroendocrine measures is enhanced by using a multihormonal profile.

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