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The American Journal of Psychiatry, VOL. 139, No. 9

REGULAR ARTICLES | September 01, 1982

Corneal and lenticular opacities in mentally retarded young adults treated with thioridazine and chlorpromazine

Am J Psychiatry 1982;139:1178-1180.

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Abstract

Of 18 mentally retarded institutionalized subjects who had received long-term, high-dose treatment primarily with thioridazine or chlorpromazine, 2 developed definite corneal and lenticular opacities and 2 had equivocal ocular changes. In view of this finding, the authors suggest that alternative treatment, including different neuroleptics, be considered with mentally retarded institutionalized subjects; when that is not possible, subjects should be given periodic evaluation, including annual slit-lamp examination.

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