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The American Journal of Psychiatry, VOL. 139, No. 9

REGULAR ARTICLES | September 01, 1982

Lecithin in the treatment of mania: double-blind, placebo-controlled trials

Am J Psychiatry 1982;139:1162-1164.

An erratum to this article has been published | view the erratum

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Abstract

The authors report double-blind, placebo-controlled trials of pure lecithin in the treatment of mania. As in preliminary trials, lecithin appeared to be nontoxic and effective. Improvement with lecithin was significantly greater than improvement with placebo in five of the six patients studied. The concurrent use of anticholinergic agents did not prevent the antimanic effect of lecithin. The authors discuss the possible mechanism of action of lecithin, including cholinergic and membrane-altering effects.

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