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The American Journal of Psychiatry, VOL. 139, No. 8

REGULAR ARTICLES | August 01, 1982

Controlled trial of zimelidine, a 5-HT reuptake inhibitor, for treatment of depression

Am J Psychiatry 1982;139:1057-1058.

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Abstract

The authors conducted a double-blind, placebo-controlled clinical trial of the selective 5-HT reuptake inhibitor zimelidine in the treatment of major depressive illness. Zimelidine had the same antidepressant efficacy as amitriptyline but significantly fewer side effects, especially anticholinergic effects.

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