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The American Journal of Psychiatry, VOL. 139, No. 8

REGULAR ARTICLES | August 01, 1982

RBC and plasma levels of haloperidol and clinical response in schizophrenia

Am J Psychiatry 1982;139:1054-1056.

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Abstract

The authors conducted a fixed-dose study of haloperidol blood levels and clinical response in schizophrenic in patients and found that those with steady-state RBC haloperidol levels in the range of 2.4--5.4 ng/ml showed greater improvement than those with lower or higher levels. They found a similar , although nonsignificant, curvilinear relationship between plasma haloperidol levels and clinical response. These findings suggest that the relationship between haloperidol blood levels and clinical response fits a therapeutic window for the treatment of schizophrenia.

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