The authors completed ratings of premorbid sexual and social adjustment
and assays of the CSF homovanillic acid (HVA), 5-hydroxyindoleacetic acid
(5-HIAA), and probenecid concentrations in 108 psychiatric patients. Among
the 30 patients diagnosed as schizophrenic, poor premorbid sexual
adjustment was associated with higher accumulations of HVA in the CSF. No
relationship between the estimated premorbid social adjustment and CSF HVA
levels was observed. These findings suggest that 1) sexual and social
premorbid adjustment are partially independent variables, and 2) one of the
biological correlates of sexual adjustment in schizophrenic patients may be
the functional maturity of central dopamine systems.Abstract Teaser