The authors studied the effect of LRH and TRH on HGH in 10 adolescent
schizophrenic boys and 9 age-matched normal boys. Before antipsychotic
treatment, LRH and TRH induced a marked rise in hGH in 8 of 10 patients and
4 of 6 patients, respectively. No effect on HGH was observed in the normal
controls. After 3 months of treatment with chlorpromazine, thioridazine, or
haloperidol, LRH failed to induce a rise in HGH in 5 of the 6 patients
tested, but TRH induced a significant rise in HGH in 3 of 4 patients
tested. The authors postulate that these results indicate a dysfunction in
the mechanism regulating HGH secretion in schizophrenia.Abstract Teaser