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The American Journal of Psychiatry, VOL. 138, No. 12

REGULAR ARTICLES | December 01, 1981

Induction of rapid mood cycling during L-dopa treatment in a bipolar patient

Am J Psychiatry 1981;138:1624-1625.

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Abstract

The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic- depressive cycle length when administered in a double-blind trial. This finding suggests a dopaminergic mechanism specifically in changing the frequency of cycling between depression and mania.

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