Seven elderly depressed women were given desipramine, and plasma
concentrations of the drug were measured from blood samples drawn after a
single dose and during long-term use. The concentrations were no different
from those found in younger patients. Aging does not seem to alter the
plasma concentration of desipramine, and the authors conclude that the
increased incidence and severity of the drug's side effects are probably
not due to high drug concentrations.Abstract Teaser