Newly admitted schizophrenic patients (N=48) were given a test does of
2.2 mg/kg of chlorpromazine hydrochloride by mouth. Chlorpromazine was
measured in plasma and saliva at 1, 2, 3 (saliva only), 4, 6, 8, 12 (saliva
only), and 24 hours by gas chromatography-mass spectography. Subjective
response at 4 and 24 hours after test dose was not significantly related to
either plasma or saliva level even for dysphoric responders. Dyschoric
responses to chlorpromazine appear to be idiosyncratic--rooted perhaps in
altered recepter sensitivity or in a patient's very personal interpretation
of drug effect.Abstract Teaser