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The American Journal of Psychiatry, VOL. 137, No. 9

REGULAR ARTICLES | September 01, 1980

MHPG as a predictor of antidepressant response to imipramine and maprotiline

Am J Psychiatry 1980;137:1090-1092.

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Abstract

To explore the hypothesis that depressed patients with low pretreatment levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) respond more favorably to antidepressant drugs which act on noradrenergic neuronal systems than do patients with high MHPG levels, the authors administered 150--200 mg/day of imipramine or maprotiline to 13 depressed patients. All of the 5 patients with low pretreatment MHPG levels responded to treatment compared with 1 of the 14 patients with high MHPG levels; 4 patients dropped out of the study.

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