The authors describe a fatal episode of intestinal dilatation associated
with chlorpromazine therapy. A total of 26 similar cases associated with
phenothiazine or tricyclic antidepressant therapy, including 9 fatalities,
has been reported in the literature. The authors cite experimental evidence
supporting this association. They emphasize the difficulty of recognizing
this syndrome in the psychotic patient; careful evaluation is indicated in
the constipated patient who exhibits vomiting, abdominal pain, distension,
or tenderness.Abstract Teaser