Twenty patients with a history of treatment-resistant obsessional
neurosis underwent a 4-week clinical trial of chlorimipramine. Scores on
the Psychiatric Questionnaire for Obsessive Compulsive Neurosis, the Leyton
Obsessional Inventory, and 3 self-assessments indicated that although there
was no significant change in obsessive ruminations, obsessive rituals,
horrific temptations, or pervading doubt, there was a substantial
significant improvement in the obsessive symptom item and severity of
obsessions, as well as anxiety, depression, and phobia. Side effects were
mild. The authors believe that chlorimipramine is the most promising
treatment for obsessive-compulsive neurosis.Abstract Teaser