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The American Journal of Psychiatry, VOL. 136, No. 12

REGULAR ARTICLES | December 01, 1979

Choline chloride in schizophrenia

Am J Psychiatry 1979;136:1581-1584.

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Abstract

The authors investigated the possibility that choline chloride might reduce schizophrenic symptoms by increasing central cholinergic activity. In a single blind crossover study, up to 20 g/day of choline chloride had no significant effect on clinical ratings of nine schizophrenic patients. However, there was some evidence that choline significantly increased symptoms of depression.

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