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The American Journal of Psychiatry, VOL. 135, No. 7

REGULAR ARTICLES | July 01, 1978

Effect of haloperidol and apomorphine treatment on dopamine receptors in pituitary and striatum

Am J Psychiatry 1978;135:839-841.

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Abstract

Prompted by an interest in the similarity of brain and tuberoinfundibular systems, the authors studied butaclamol-specific neuroleptic and apomorphine binding in pituitary and striatum after chronic haloperidol and acute apomorphine treatment. Striatal binding increases but pituitary binding decreases in haloperidol-treated rats. Pituitary binding changes rapidly in response to apomorphine exposure and striatal binding does not. These findings suggest that factors influencing binding differ in these two tissues.

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