Although a 1-week supply of tricyclic antidepressants is generally
considered safe, the author shows that this amount can be severely toxic.
Six of 12 instances of low-dose (500-1000 mg) amitriptyline overdoses were
life threatening. The author suggests that prescription guidelines for
tricyclic antidepressants be tightened and that physicians prescribe less
than a 1-week supply to potentially suicidal patients.Abstract Teaser