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The American Journal of Psychiatry, VOL. 134, No. 3

REGULAR ARTICLES | March 01, 1977

Phenothiazine-induced bulbar palsy-like syndrome and sudden death

Am J Psychiatry 1977;134:308-311.

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Abstract

There have been periodic case reports of sudden death due to aspiration or asphyxiation in patients receiving phenothiazines. The mechanism of death is unknown. The author reports a case of a drug-induced bulbar palsy-like syndrome in a man receiving fluphenazine enanthate and reviews the literature on sudden respiratory death and phenothiazines. He postulates that phenothiazine-induced bulbar palsy may cause laryngeal and/or pharyngeal dysfunctions that are responsible for aspiration.

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