The authors treated two children with Gilles de la Tourette's disease
and one child with a probable combination of Gilles de la Tourette's
disease and minimal brain dysfunction with methylphenidate, which resulted
in exacerbation of symptoms. One child was briefly treated with imipramine,
with similar results. The authors suggest that these pharmacologic agents
should be used cautiously in treating patients with possible movement
disorders (tics) and conclude that their findings lend support to the
catecholamine hypothesis of the etiology of Gilles de la Tourette's
disease.Abstract Teaser