Platelet MAO activity decreased by 40% (p less than .001) in a group of
11 male patients with primary depression after 3 weeks of treatment with
either amitriptyline or imipramine. This finding, together with data from
previous in vitro studies demonstrating tricyclic-induced inhibition of
mitochondrial MAO, suggests that inhibition of MAO plays a role in the
clinical action of tricyclic antidepressant drugs.Abstract Teaser