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The American Journal of Psychiatry, VOL. 134, No. 2

REGULAR ARTICLES | February 01, 1977

Protriptyline: an effective agent in the treatment of the narcolepsy- cataplexy syndrome and hypersomnia

Am J Psychiatry 1977;134:183-185.

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Abstract

The authors present five case reports illustrating that 10-20 mg of protriptyline in a single dose at bedtime can effectively control arousal dysfunction (sleep drunkenness and hypersomnia) and the narcolepsycataplexy syndrome without the apparent development of tolerance and without the side effects that are frequent complications of treatment with other agents. Although protriptyline was efficacious in controlling symptoms, it was found to have relatively poor REM sleep- suppressing properties.

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