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The American Journal of Psychiatry, VOL. 134, No. 12

REGULAR ARTICLES | December 01, 1977

Increased sympathetic nervous system activity in alcoholic patients treated with disulfiram

Am J Psychiatry 1977;134:1411-1414.

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Abstract

The authors measured plasma levels of norepinephrine (NE) and dopamine beta-hydroxylase (DBH), pulse rates, and blood pressures of 81 hospitalized alcoholic patients. Treatment with 500 mg/day of disulfiram (but not 250 mg/day or placebo) resulted in small but significant increases in plasma NE and in blood pressure. The 500-mg dose did not appreciably inhibit DBH. Patients receiving high doses of disulfiram should have their blood pressure monitored and their dose decreased to 250 mg/day when possible.

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