Sulpiride is a new and chemically different neuroleptic. In a study of
16 severely ill schizophrenic patients, this compound displayed definite
evidence of antipsychotic activity while producing few adverse reactions.
The relative absence of extrapyramidal side effects may indicate that
sulpride has a low potential for producing tardive dyskinesia. Two patients
who did not develop significant increases in prolactin levels did show a
definite therapeutic response to sulpiride. Thus it appears that central
dopaminergic blockade in the hypothalamic area is not a prerequisite for
antipsychotic activity.Abstract Teaser