The authors analyzed the results of a multihospital collaborative study
on the effectiveness of lithium prophylaxis in recurrent depression in
terms of dosage and found that serum lithium levels between 0.5 and 0.7
mEq/liter and doses below 1000 mg/day were relatively ineffective in
preventing recurrences. Serum lithium levels between 0.8 and 1.0 mEq/liter
and doses above 1000 mg/day were associated with a relatively low failure
rate. The authors discuss the relevance of these findings to current
prescription guidelines for lithium carbonate.Abstract Teaser