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The American Journal of Psychiatry, VOL. 133, No. 2

REGULAR ARTICLES | February 01, 1976

The dopamine hypothesis of schizophrenia: focus on the dopamine receptor

Am J Psychiatry 1976;133:197-202.

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Abstract

Alleviation of schizophrenic symptoms by phenothiazines and butyrophenones is associated with blockade of dopamine receptors, while exacerbation of symptoms by amphetamines appears to result from enhanced synaptic activity of dopamine and/or norepinephrine. The author suggests that biochemical labeling of the dopamine receptor with 3H-dopamine and 3H-haloperidol may clarify mechanisms of drug effects on the dopamine receptor.

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