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The American Journal of Psychiatry, VOL. 133, No. 1

Special Articles | January 01, 1976

Overview: maintenance therapy in psychiatry: II. Affective disorders

Am J Psychiatry 1976;133:1-13.

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Abstract

In the first part of this overview the author reviewed the clinical literature on prophylactic treatment of schizophrenia with maintenance antipsychotic drugs. In this second part he reviews the literature on maintenance treatment of affective disorders with lithium and tricyclics. He concludes that the growing realization that maintenance treatment is necessary to prevent recurrences of both mania and depression in bipolar disease and depression in unipolar disease is one of the most important advances in psychiatric therapeutics. The effectiveness of maintenance treatment provides the potential for a truly preventive approach to the treatment of affective disorders.

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